Bioavailability of Sea Urchin to Aquatic Toxicity Tests

Echinoderms a wide range of valuable biological processes can be considered and can be relevant for Eco toxicological analyses. As is well known the effects of toxic chemicals and complex mixtures on early developmental stages of aquatic organisms are of great importance in the protection of the natural population’s health.

The sea urchin is one of the most sensitive and suitable test organisms for acute bioassay of pollution. The use of sea urchin embryos and gametes in testing developmental, reproductive and cytogenetic effects of chemicals and complex mixtures has been successfully developed by a number of laboratories worldwide.

The use of multispecies tests capable of accounting for the differences in sensitivity of different species to different contaminants.

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Computer assisted SOMFA Tool Validation using 3D-QSAR Study on Selective Inhibitors of Glucagon Receptor

Cheminformatics is the mixing of information resources to transform data into information and transformation of information for the decision making in the area of drug design and devlopement.

Cheminformatics involving application of computational and information tools for a range of problems in the field of drug design.It is a interconnection of computer science

and drug design for storing, retrieving, searching of information along with data.

A wide variety of computational tools are available for studying behavior of molecules which has been proved to be meaningful for designing novel molecules.Threedimensional quantitative structure-activity relations (3D-QSAR), is emerged as a powerful Cheminformatics technique which changed the area of drug discovery.

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Effect of Knee-Ankle-Foot Orthosis (KAFO) on Knee Kinematics and Kinetics in an Individual with Knee Varus Alignment

The medial compartment knee osteo arthritis (OA) is the most affected location for OA. The main knee biomechanics changes which are associated with the medial compartment knee OA are less knee flexion value (the normal mean maximum knee flexion has been shown to be 64.6° during walking, 98.6° during ascending, and 90.3 °during descending), high knee varus angle and an increased the external knee adduction moment(EKAM) during walking and stairs climbing due to shifting the knee joint centre more laterally and the centre of the load medially.

Knee-Ankle-Foot Orthosis

These changes lead to pain during daily activities and progression of the knee OA. The EKAM is considered as the most important variable in the frontal plan and has two peaks: The first peak is a sharp one after initial contact during early stance phase, while the second one is in the late stance phase. The first peak is affected by the amount of knee varus, joint space narrowing, OA severity, and progression level, while the second one is more correlated to the amount of toe out and pain levels. Read more>>>>>>

Direct Shoot Organogenesis from Juvenile Cotyledon of Jatropha podagrica Hook

Jatropha podagrica is a shrub commonly known as coral nut, Guatemala Rhubarb and physic nut; and it belongs to family Euphorbiaceae. It is a tropical America innate, but similarly common in southern part of Africa, Australia and warmer portions of Asia.

Jatropha podagrica Hook

Jatropha originate from “jatros” the Greek word which means doctor also ‘‘trophe’’ food, that suggests the therapeutic practises. J. podagrica under the tribe Joannesieae of the family Euphorbiaceae comprises about 165-170 identified types worldwide primarily in tropical and subtropical areas. Jatropha is a tremendously adaptive plant thus it can grow in dry lands and degraded soils. J. podagrica is a very significant plant. It is a rich source of biologically active compounds, used for antimicrobial activities. It is also a famous ornamental plant and most remarkably, a promising biodiesel plant. Some of the many secondary metabolites extracted from J. podagrica are scoparone, 3-Acetylaleuritolic acid, fraxidin, japodic acid and erythrinasinate. Seed oil content varies among species from 30-38%. Farming of the Jatropha plant is a promising source of renewable energy (biodiesel oil). Read more>>>>>> 

Averaged and Personalized Mathematical Modeling of Biomechanics of a System Limb-Orthosis

Despite the growing use of orthoses in clinic, sports and everyday life, and availability of a number of medical guides and atlases for orthoses the line of activity, involvingmechanical and mathematical modeling of "Leg-Orthosis" system, is as yet only at the beginning of its development.

Orthosis

Publications relating to modeling limbs orthotics per se (biomechanics of foot and insoles constitutes actually a separate independent area of research) by methods of solid mechanics, are isolated yet, and they relate only to orthosis itself and completely ignore the very limb and its mechanical properties. At the same time such studies are needed to resolve a number of important issues. For example, it is known that the rate of tissue regeneration depends on the loading level and program. It is therefore important to find out whether it is possible to control the limb unloading in an orthosis – for example, through a change in the orthosis lateral compression, etc. Read more>>>>>>>

Effect of (He-Ne) Laser on Etching Parameters of CR-39 Irradiated with Alpha Particles

The effect (He-Ne) laser on the registration properties of alpha particle tracks on CR-39 track detector was studied. CR-39 detectors were exposed to different powers (1, 5 and 10 mW) of He-Ne laser beam at different times (5, 10 and 15 min) and then irradiated to alpha-particles from 226Ra source (laser+α). Track diameters (D), track density

(ρ)    were determined using 6.25 N NaOH at 60°C.

Bulk etching rate (VB), track etching rate (VT), critical angle (Өc), etching efficiency (η), Sensitivity (S), etching ratio rate (V) were calculated.

It’s found increase in the values of (D, ρ, VB, VT and Өc) with increase in the exposure times of laser at each power case, and decrease in the values of (η, S and V) with increase in the exposure time of laser at 1 mw power, while increasing within increase of exposed times of laser at (5 and 10 mW).

The optimum etching time of CR-39 detectors was (4 h) with NaOH etchant solation and 6.25 at temperature 60oC.

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Sporotrichosis: An Infectious Emerging Mycosis of Zoonotic Potential

Sporotrichosis (Berumann`s disease, peat moss disease, rose gardener’s disease, Schenck`s disease) is an infectious, subcutaneous or chronic granulomatous mycotic disease of humans aswell as animals. It is a life- threatening disease in immune compromised patients.

Sporotrichosis

Sporotrichosis is considered as an emerging zoonotic fungal disease in many regions of the world. An American researcher Benjamin Schenck is credited to identify the organism for the first time in 1898. The presence of asteroid bodies in pus from cutaneous lesions was first time noticed by Slendore in 1908. In 1920, Ghosh described the first case of sporotrichosis from Kolkata, which established the endemic focus of infection in the North-eastern belt of India. The disease is endemic in many regions of the world including India. Sporotrichosis is a disease of occupational risk, affecting agricultural workers, farmers, gardeners, and mine workers.Read more>>>>>

Green Synthesis of Silver Nanoparticles from Punica granatum L. and Its Antimicrobial Activity

Green synthesis of nanoparticles was done from Punica granatum L. by using Silver nitrate (AgNO3) from the exocarp, mesocarp and the juice of Aarakta, a local variety of Maharashtra, India.

In this work, we have explored an inventive contribution for synthesis of silver nanoparticles using the peel (exocarp and mesocarp) and the seed juice of pomegranates. The procedures for development of stable silver nanoparticles were characterized.

The synthesis of nanoparticles was confirmed through UV-Visible spectroscopy. The interaction between nanoparticles with functional groups was confirmed by using FT-IR and PCA was performed. The antimicrobial activity of these pomegranate synthesized silver nanoparticles was evaluated against different microorganisms viz. Escherichia coli, Pseudomonas aeruginosa and Proteus vulgaris.

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